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A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity, Org. Lett., 2010, 12: 3196–3199
发布时间:2020-03-07 阅读数:1445 来源:原创
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Fei Wang †,§, Yuan Gao §, Ling Zhang , Bing Bai, Ya Nan Hu , Ze Jun Dong , Qi Wei Zhai *,‡, Hua Jie Zhu *,†, and Ji Kai Liu *,


State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China 

§ BioBioPha Co. Ltd., Kunming 650204, People’s Republic of China

Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Tai-Yuan Road, Shanghai 200031, People’s Republic of China


Abstract

(+)-Linderaspirone A and (-)-linderaspirone A, a pair of natural windmill-shaped enantiomers, were isolated from the traditional Chinese medicine plant Lindera aggregate by HPLC using a chiral column, achieving over 98% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra, crystal X-ray diffraction, and calculation of the optical rotations (OR). They have an unprecedented carbon skeleton and showed significant activity against glucosamine-induced insulin resistance.


文章链接:https://pubs.acs.org/doi/abs/10.1021/ol1011289

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