Fei Wang ^†,‡, Yuan Gao ^‡, Ling Zhang ^†, and Ji-Kai Liu ^*,†

^† State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China 

^‡ BioBioPha Co. Ltd., Kunming 650204, People’s Republic of China

Abstract

Bi-linderone (1) was isolated as racemate from the traditional Chinese medicinal plant Lindera aggregata. The structure elucidation of bi-linderone was reported on the basis of extensive analysis of NMR spectra and crystal X-ray diffraction. Bi-linderone has an unprecedented spirocyclopentenedione-containing carbon skeleton and showed significant activity against glucosamine-induced insulin resistance in HepG2 cells at a concentration of 1 µg/mL.

文章链接：https://pubs.acs.org/doi/abs/10.1021/ol1007247