Xiang-Mei Li ^a,b , Cheng-Mei Yang ^a,b , Li-Na Zhang ^a,b , Xian-Jun Jiang ^a,b , Guo-Zhu Wei ^{a,b, *}, Fei Wang ^{a,b, *} 

^a BioBioPha Co., Ltd., Kunming, 650201, People’s Republic of China

^b Reference Substance Branch, National Engineering Research Center for Modernization of Traditional Chinese Medicine, Kunming, 650201, People’s Republic of China 

Abstract

Four hitherto unknown triterpenoids, including one euphane, namely wilfordeuphone (1), and three friedelanes, namely wilforic acids G − I (2–4), were isolated from the ethanol extract of the roots of Tripterygium wilfordii. The absolute configuration of 1 was established by single crystal X-ray diffraction. In addition, this study is the first to report euphane-type triterpenoid in the genus Tripterygium. Compound 1 exhibited the moderate cytotoxic activity when evaluated against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480), with IC50 values ranging from 14.0–26.7 μM. 

文章链接：https://doi.org/10.1016/j.phytol.2021.10.016