Fei Wang †,‡, Yuan Gao ‡, Ling Zhang †, and Ji-Kai Liu *,†
† State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China
‡ BioBioPha Co. Ltd., Kunming 650204, People’s Republic of China
Abstract
Bi-linderone (1) was isolated as racemate from the traditional Chinese medicinal plant Lindera aggregata. The structure elucidation of bi-linderone was reported on the basis of extensive analysis of NMR spectra and crystal X-ray diffraction. Bi-linderone has an unprecedented spirocyclopentenedione-containing carbon skeleton and showed significant activity against glucosamine-induced insulin resistance in HepG2 cells at a concentration of 1 µg/mL.
文章链接:https://pubs.acs.org/doi/abs/10.1021/ol1007247